Pkr - Pots



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PKR - Pots:

Deze abstract gaat over onderzoek naar abnormaliteiten bij COI & POTS.
COI    =   Chronic orthostatic intolerance
POTS =   postural tachycardia syndrome (POTS

Postural orthostatic tachycardia syndrome (POTS, also postural tachycardia syndrome) is a condition of dysautonomia,[1] more specifically orthostatic intolerance, in which a change from the supine position to an upright position causes an abnormally large increase in heart rate, called tachycardia. Several studies show a decrease in cerebral blood flow with systolic and diastolic cerebral blood flow (CBF) velocity decreased 44% and 60%, respectively.[2] Patients with POTS have problems maintaining homeostasis when changing position, i.e. moving from one chair to another or reaching above their heads. Many patients also experience symptoms when stationary or even while lying down.

Increasing orthostatic stress impairs neurocognitive functioning in Chronic Fatigue Syndrome with Postural Tachycardia Syndrome.Symptoms present in various degrees of severity depending on the patient. POTS can be severely debilitating. Some patients are unable to attend school or work, and especially severe cases can completely incapacitate the patient.

Studies have indicated a high degree of association between POTS and CFS. "POTS is sometimes found in Fibromyalgia," and "POTS may share a common pathophysiology with CFS." POTS is a disorder characterized by a pulse/heart rate that is too fast when the patient stands. Our preliminary data have shown that POTS physiology underlies orthostatic intolerance in the large majority of adolescents with the chronic fatigue syndrome

Proteins are categorized into functional groups (some might exist within multiple categories)

New lab markers for CFS

The precise nature and cause of CFIDS is not clear at this time. However, recent studies have shown :

Researchers supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases have discovered that an enzyme called calcium/calmodulin-dependent protein kinase (CaMK) is a major player in activating "slow-twitch" muscles

PKC and bipolar disorder-Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro.

Immunological abnormalities in cfs/me

Expression of endogenous retrovirus sequences in immune dysfunction disorders in humans

RNase L in health and disease: what did we learn recently?

Chronic Fatigue Syndrome/ME and Fibromyalgia plus Associated Syndromes. Evidence for their organic basis: A summary of the suggested underlying pathophysiologies and treatment approaches

CFS - Is prolonged exposure to environmental level power line frequency electromagnetic fields a co-factor to consider in treatment?

Induction of neurite outgrowth through contacting and Nr-cam by extra cellular regions of glial receptor tyrosine phosphatase

The authors present for the first time evidence for enteroviral persistence in humans based on sequence comparison of serial PCR products from the 5' non-translated region (NTR).

Fibromyalgia: An oxidative-dysoxygenative disorder